||Assistant Professor - Department of Neuroscience|
Assistant Professor - Department of Molecular and Cellular Biology
Ph.D., University of Nantes, France, 2002
One Baylor Plaza
Baylor College of Medicine
Houston TX, 77030
Telephone: 713-798-8913 - Fax: 713-798-3946
The goal of my laboratory is to study the molecular and cellular mechanisms, as well as the neuronal circuitry, underlying long-term synaptic plasticity, learning and memory. I believe that by studying the mechanisms underlying long-lasting synaptic plasticity and mnemonic processes we can generate corresponding insights into human cognitive disorders.
Our prior work established a critical role for translational control in long-lasting forms of synaptic plasticity and memory formation. Currently, our lab studies the molecular and cellular mechanism underlying long-lasting synaptic plasticity and memory. To study these processes, in a multidisciplinary approach, we combine, transgenic manipulation, shRNA and miRNA delivery using lentiviral vectors, biochemical, imaging, behavioral and in vitro and in vivo neurophysiological methodologies.
In a complementary line of research, we intend to elucidate the mechanisms linking translational control with developmental disorders such as Autism and mental retardation and other neurological disorders such as Alzheimer's disease.
Costa-Mattioli M, Sossin WS, Klann E, Sonenberg N. Translational control of long-lasting synaptic plasticity and memory. Neuron. 2009 Jan 15;61(1):10-26.
Petroulakis E, Parsyan A, Dowling RJ, LeBacquer O, Martineau Y, Bidinosti M, Larsson O, Alain T, Rong L, Mamane Y, Paquet M, Furic L, Topisirovic I, Shahbazian D, Livingstone M, Costa-Mattioli M, Teodoro JG, Sonenberg N. p53-dependent translational control of senescence and transformation via 4E-BPs. Cancer Cell. 2009 16(5):439-46.
Patel PH, Costa-Mattioli M, Schulze KL, Bellen HJ. The Drosophila deoxyhypusine hydroxylase homologue nero and its target eIF5A are required for cell growth and the regulation of autophagy. J Cell Biol. 2009 185 (7):1181-94
Costa-Mattioli M. Eppendorf winner. Switching memories ON and OFF. Science. 2008 Nov 7;322(5903):874-5.
Napoli, I., Mercaldo, V., Boyl, P. P., Eleuteri, B., Zalfa, F., De Rubeis, S., Di Marino, D., Mohr, E., Massimi, M., Falconi, M., Witke, W., Costa-Mattioli, M., Sonenberg, N., Achsel, T., Bagni, C. (2008). The fragile X syndrome protein represses activity-dependent translation through CYFIP1, a new 4E-BP. Cell 134:1042-54.
Costa-Mattioli M, Sonenberg N. (2008). RAPping production of type I interferon in pDCs through mTOR. Nat. Immunol 9 1097-9.
Colina, R*., Costa-Mattioli, M*#., Dowling, R. J., Jaramillo, M., Tai, L. H., Breitbach, C. J., Martineau, Y., Larsson, O., Rong, L., Svitkin, Y. V., Makrigiannis, A. P., Bell, J. C., Sonenberg, N#. (2008). Translational control of the innate immune response through IRF-7. Nature 452 323-8. Epub 2008 Feb 13. *equal contribution; #corresponding author
#Costa-Mattioli, M., Gobert, D., Stern, E., Gamache, K., Cuello, C., Sossin, W., Kaufman R., Pelletier, J., Rosenblum, K., Krnjevic, K., Lacaille, J-C., Nader, K., and Sonenberg, N. (2007). eIF2a phosphorylation regulates the switch from short to long-term synaptic plasticity and memory. Cell 129, 195-206. #corresponding author
- An atomic switch for memory Cell (2007) 129 23-4.
- Switching Gears: Translational Mastery of Transcription during Memory Formation. (2007) Neuron 54, 186-9.
Karim, M. M., Svitkin, Y.V., Kahvehian, A., De Crescenzo, G., Costa-Mattioli, M., Sonenberg, N. (2006). A mechanism of translational repression by competition of Paip2 with eIF4G for poly(A) binding protein (PABP) binding. Proc Natl Acad Sci U S A 103 9494-99.
Costa-Mattioli, M., Gobert, D., Harding, H., Herdy, B., Azzi, M., Bruno, M., Bidinosti, M., Ben Mamou, C., Marcinkiewicz, E., Yoshida, M., et al. (2005). Translational control of hippocampal synaptic plasticity and memory by the eIF2alpha kinase GCN2. Nature 436, 1166-73.
Awards, Recognition, Appointments, and Honors
1999-2001: PhD Fellowship from the French government (Ministry of foreign relations).
2001-2002: PhD fellowship: United Nation of Educational and Cultural Organization (UNESCO).
2003-2006: Post-doctoral fellowship. Canadian Institutes of Health Research (CIHR).
2007: International Recognition: International Commission of Affairs, The House of Representatives, Montevideo, Uruguay.
2008: Eppendorf-Science International Grand Prize in Neurobiology.
2009: Searle Scholar Award.
Current Graduate Students
- Dillon Baete (Neuroscience)
- Wei Huang (Neuroscience)
- Jennifer Johnson (Neuroscience)
- Loredana Stoica (MCB)